S-layer stabilized lipid membranes (Review)

Polymer Stabilized Lipid Membranes: Langmuir Monolayers

Polymer-tethered membranes combine fascinating structural, dynamic, and viscoelastic properties. Many important insights into these peculiar supramolecular systems can be obtained from studies on polymer-tethered monolayers. This chapter discusses recent experimental findings on polymer-tethered monolayers at the air–water interface. In particular, Langmuir monolayers which are comprised of pur...

Biomimetic interfaces based on S-layer proteins, lipid membranes and functional biomolecules.

Designing and utilization of biomimetic membrane systems generated by bottom-up processes is a rapidly growing scientific and engineering field. Elucidation of the supramolecular construction principle of archaeal cell envelopes composed of S-layer stabilized lipid membranes led to new strategies for generating highly stable functional lipid membranes at meso- and macroscopic scale. In this rev...

Releasable layer-by-layer assembly of stabilized lipid nanocapsules on microneedles for enhanced transcutaneous vaccine delivery.

Here we introduce a new approach for transcutaneous drug delivery, using microneedles coated with stabilized lipid nanocapsules, for delivery of a model vaccine formulation. Poly(lactide-co-glycolide) microneedle arrays were coated with multilayer films via layer-by-layer assembly of a biodegradable cationic poly(β-amino ester) (PBAE) and negatively charged interbilayer-cross-linked multilamell...

Lipid Membranes

Dynamically stabilized pores in bilayer membranes.

Zhelev and Needham have recently created large, quasistable pores in artificial lipid bilayer vesicles. Initially created by electroporation, the pores remain open for up to several seconds before quickly snapping shut. This result is surprising, in light of the large line tension for holes in bilayer membranes and the rapid time scale for closure of large pores. We show how pores can be dynami...